Publications

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Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer

Yuanjian Huang,* Shengzhe Zhang,* Jae-Il Park

Accepted

Preprint

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A New Murine Esophageal Organoid Culture Method and Organoid-Based Model of Esophageal Squamous Cell Neoplasia

Biyun Zheng,* Kyung-Pil Ko,* Xuefen Fang, Xiaozhong Wang, Jie Zhang, Sohee Jun, Bong-Jun Kim, Wenyi Luo, Moon Jong Kim, Youn-Sang Jung, Christopher L. Cervantes, Jae-Il Park

iScience   2021 Nov 15; 103440, DOI:https://doi.org/10.1016/j.isci.2021.103440 

scRNA-seq data (GSE174577)

Supplemental Information (PDF)

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Yap/Taz-Activated Tert-Expressing Acinar Cells Are Required for Pancreatic Regeneration

Han Na Suh, Moon Jong Kim, Sung Ho Lee, Sohee Jun, Jie Zhang, Randy L Johnson, and Jae-Il Park

BioRxiv   BioRxiv 2021 Sep; doi: https://doi.org/10.1101/2021.08.30.458292

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PAF Remodels the DREAM Complex to Bypass Cell Quiescence and Promote Lung Tumorigenesis 

Moon Jong Kim, Christopher Cervantes, Youn-Sang Jung, Xiaoshan Zhang, Jie Zhang, Sung Ho Lee, Sohee Jun, Larisa Litovchick, Wenqi Wang, Junjie Chen, Bingliang Fang, and Jae-Il Park

Molecular Cell   2021 Feb 17;S1097-2765(21)00087-3, doi: 10.1016/j.molcel.2021.02.001, PMID: 33626321, PMC8052288.     Supplementary Information (PDF)

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TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis

Youn-Sang Jung, Sabrina Stratton, Sung Ho Lee, Moon Jong Kim, Sohee Jun, Jie Zhang, Biyun Zheng, Michelle C. Barton, Jae-Il Park

Hepatology   2021 Feb;73(2):776-794. doi: 10.1002/hep.31305. Epub 2020 Nov 17. PMID: 32380568; PMCID: PMC7062731.     Supplementary Information (PDF)

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A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia

Xi Shen, Rui Wang, Moon Jong Kim, Qianghua Hu, Chih-Chao Hsu, Jun Yao, Naeh Klages-Mundt, Yanyan Tian, Erica Lynn, Thomas F. Brewer, Yilei Zhang, Banu Arun, Boyi Gan, Michael Andreeff, Shunichi Takeda, Junjie Chen, Jae-il Park, Xiaobing Shi, Christopher J. Chang, Sung Yun Jung, Jun Qin, Lei Li

Molecular Cell   2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. PubMed PMID: 33338401.

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Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views

Moon Jong Kim,* YuanJian Huang,* Jae-Il Park

Cancers (Basel)   2020 Dec 4;12(12). doi: 10.3390/cancers12123638. PubMed PMID: 33291655.

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Blockers of Wnt3a, Wnt10a or β-catenin prevent chemotherapy-induced neuropathic pain in vivo

Hee Kee Kim, Jingi Bae, Sung Ho Lee, Seon-Hee Hwang, Min-Sik Kim, Moon Jong Kim, Sohee Jun, Chris L. Cervantes, Youn-Sang Jung, Seunghoon Back, Hangyeore Lee, Seung-Eun Lee, Patrick M Dougherty, Sang-Won Lee, Jae-Il Park, Salahadin Abdi

Neurotherapeutics   2020 Oct 30. PMID: 33128175; DOI: 10.1007/s13311-020-00956-w

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Wnt Signaling in Cancer: Therapeutic Targeting of Wnt Signaling beyond β-Catenin and Destruction Complex 

Youn-Sang Jung, Jae-Il Park

Experimental Molecular Medicine   2020 Feb 10;. doi: 10.1038/s12276-020-0380-6. PMID: 32037398, PMCID: PMC7062731

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LncGata6-Controlled Stemness in Regeneration and Cancer

Youn-Sang Jung,* Moon Jong Kim,* Jae-Il Park  

Non-coding RNA Investig   pii: 4. doi: 10.21037/ncri.2019.01.02., 1/2019, PMCID: PMC6377203

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TMEM9 Promotes Intestinal Tumorigenesis via v-ATPase-Activated Wnt/β-Catenin Signaling 

Youn-Sang Jung,* Sohee Jun,* Moon Jong Kim, Sung Ho Lee, Han Na Suh, Esther M. Lien, Hae-Yun Jung, Sunhye Lee, Jie Zhang, Jung-In Yang, Hong Ji, Ji Yuan Wu, Wenqi Wang, Rachel K. Miller, Junjie Chen, Pierre D. McCrea, Scott Kopetz, Jae-Il Park 

Nature Cell Biology   20, 1421-1433, 12/2018, PMCID: PMC6261670.   Supplementary Information (PDF)

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PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis

Moon Jong Kim, Xia Bo, Han Na Suh, Sung Ho Lee, Sohee Jun, Esther M. Lien, Jie Zhang, Kaifu Chen, Jae-Il Park     

Developmental Cell   44, 582-596, 3/2018  PMCID: PMC5854208.   Supplementary Information (PDF)

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Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration

Han Na Suh, Moon Jong Kim, Youn-Sang Jung, Esther M. Lien, Sohee Jun, Jae-Il Park

Cell Reports   21, 2571-2584 11/2017  PMCID: PMC5726811.     Supplementary Information (PDF)

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Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia

Suh HN,* Jun S,* Oh AY, Srivastava M, Lee S, Taniguchi CM, Zhang S, Lee WS, Chen J, Park BJ, Park JI

Scientific Reports  6:38273, 12/2016.  e-Pub 12/2016. PMCID: PMC5138641

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LIG4 mediates Wnt signalling-induced radioresistance  

Jun S,* Jung YS,* Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI

Nature Communications  7:10994, 2016.  e-Pub 3/2016. PMCID: PMC4820809

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PAF-Wnt Signaling-Induced Cell Plasticity Is Required for Maintenance of Breast Cancer Cell Stemness 

Wang X,* Jung YS,* Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI   

Nature Communications   doi:10.1038/ncomms10633:10633, 2016.  e-Pub 2/2016. PMCID: PMC4743006

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Wnt2 complements Wnt/β-catenin signaling in colorectal cancer 

Jung YS, Jun S, Lee SH, Sharma A, Park JI

Oncotarget   6(35)(35):37257-68, 11/2015. e-Pub 10/2015. PMCID: PMC4741928.

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PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation 

Jung HY, Jun S, Lee M, Kim HC, Wang X, Ji H, McCrea PD, Park JI

Molecular Cell   52(2):193-205, 10/2013. e-Pub 9/2013. PMCID: PMC4040269    

Molecular Cell Preview

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PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis 

Jun S, Lee SH, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI

Cell Reports   e-Pub 10/2013. PMCID: PMC4157353

PubMed

FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus 

Wang W, Li X, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J.

Developmental Cell   32(6):707-18, 3/2015. PMCID: PMC4374128

P120-catenin regulates REST/CoREST, and modulates mouse embryonic stem cell differentiation 

Lee M, Ji H, Furuta Y, Park JI, McCrea PD.

Journal of Cell Science  127(Pt 18):4037-51, 9/2014. e-Pub 7/2014. PMCID: PMC4163646

HIV-1 Vpr Inhibits Telomerase Activity Via EDD-DDB1-VPRB3 E3 Ligase Complex 

Wang X, Singh S, Jung HY, Yang G, Jun S, Sastry KJ, Park JI.

Journal of Biological Chemistry  288(22):15474-80, 5/2013. e-Pub 4/2013. PMCID: PMC3668709

 

Dyrk2-Associated EDD-DDB1-VprBP E3 Ligase Inhibits Telomerase by TERT Degradation 

Jung HY, Wang X, Jun S, Park JI.

Journal of Biological Chemistry   288(10):7252-62, 3/2013. e-Pub 1/2013. PMCID: PMC3591633

 

Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway 

Hong JY, Park JI, Lee M, Muñoz WA, Miller RK, Ji H, Gu D, Ezan J, Sokol SY, McCrea PD.

Journal of Cell Science   125(Pt 3):561-9, 2/2012. PMCID: PMC3367828

 

PTPN14 is required for the density-dependent control of YAP1 

Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J.

Genes and Development   26(17):1959-71, 9/2012. PMCID: PMC3435498

 

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members 

Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD.

Journal of Cell Science   123(Pt 24):4351-4365, 12/2010. e-Pub 11/2010. PMCID: PMC2995616

 

Telomerase modulates Wnt signalling by association with target gene chromatin   

Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE.

Nature   460 (7251):66-72, 7/2009.   PMCID: PMC4349391

Nature News and Views 

Nature Reviews Genetics Highlights 

 

Requirement of Wnt/beta-catenin signaling in pronephric kidney development  

Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD.

Mechanisms of Development   e-Pub 12/2008. PMCID: PMC2684468. 126(3-4):142-59, 3/2009.

 

Developmental functions of the P120-catenin sub-family

McCrea PD, Park JI.

Biochimica et Biophysica Acta   2007; 1773(1):17-33. PMID: 16942809

 

Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals

Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD.

Developmental Cell   11(5):683-95, 11/2006. PMID: 17084360.

 

Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets 

Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD.

Developmental Cell   8(6):843-54, 6/2005. PMID: 15935774.

Developmental Cell Preview

Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin 

Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM, McCrea PD.

Nature Cell Biology    6(12):1212-20, 12/2004.  e-Pub 11/2004. PMID: 15543138.

 

 

Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac 

Fang X, Ji H, Kim SW, Park JI, Vaught TG, Anastasiadis PZ, Ciesiolka M, McCrea PD.

Journal of Cell Biology   165(1):87-98, 4/2004. e-Pub 4/2004. PMCID: PMC2172091.

 

Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways 

Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG.

Oncogene   22(28):4314-32, 7/2003. PMID: 12853969.

 

Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma 

Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, Kim HJ, Chi SG.

International Journal of Cancer   104(3):318-27, 4/2003. PMID: 12569555.

 

Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer

Park BJ, Park JI, Byun DS, Park JH, Chi SG.

Cancer Research   60(11):3031-8, 6/2000. PMID: 10850453.

 

Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma 

Kang MJ, Park BJ, Byun DS, Park JI, Kim HJ, Park JH, Chi SG.

Clinical Cancer Research   6(5):1767-71, 5/2000. PMID: 10815895.

 

 

*Equally contributed authors.