Publications
WNT5A-RHOA signaling is a driver of tumorigenesis and represents a therapeutically actionable vulnerability in small cell lung cancer
Kee-Beom Kim, Dong-Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bongjun Kim, Bingliang Fang, Jae-Il Park, Yi Zheng, Kwon-Sik Park
Cancer Research 14 Sep 2022, CAN-22-1170. doi: 10.1158/0008-5472.CAN-22-1170
PMID: 36102736
Establishing Transgenic Murine Esophageal Organoids
Kyung-Pil Ko, Jie Zhang, Jae-Il Park
STAR Protocols Volume 3, Issue 2, 17 June 2022, 101317, https://doi.org/10.1016/j.xpro.2022.101317
PMID: 35496812, PMCID: PMC9048136
Full-text (PDF)
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small-cell lung cancer
Kee-Beom Kim, Ashish Kabra, Dong-Wook Kim, Yongming Xue, Yuanjian Huang, Pei-Chi Hou, Yunpeng Zhou, Leilani J. Miranda, Jae-Il Park, Xiaobing Shi, Timothy P. Bender, John H. Bush welder, Kwon-Sik Park
Science Advances 2022 Feb 18;8(7):eabl4618. doi: 10.1126/sciadv.abl4618. Epub 2022 Feb 16, PMID: 35171684
Full-text (PDF)
Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer
Yuanjian Huang,* Shengzhe Zhang,* Jae-Il Park
Accepted
Biyun Zheng,* Kyung-Pil Ko,* Xuefen Fang, Xiaozhong Wang, Jie Zhang, Sohee Jun, Bong-Jun Kim, Wenyi Luo, Moon Jong Kim, Youn-Sang Jung, Christopher L. Cervantes, Jae-Il Park
iScience 2021 Nov 15; 103440, DOI:https://doi.org/10.1016/j.isci.2021.103440, PMID: 34877497, PMC8633967.
Supplemental Information (PDF)
Yap/Taz-Activated Tert-Expressing Acinar Cells Are Required for Pancreatic Regeneration
Han Na Suh, Moon Jong Kim, Sung Ho Lee, Sohee Jun, Jie Zhang, Randy L Johnson, and Jae-Il Park
BioRxiv BioRxiv 2021 Sep; doi: https://doi.org/10.1101/2021.08.30.458292
PAF Remodels the DREAM Complex to Bypass Cell Quiescence and Promote Lung Tumorigenesis
Moon Jong Kim, Christopher Cervantes, Youn-Sang Jung, Xiaoshan Zhang, Jie Zhang, Sung Ho Lee, Sohee Jun, Larisa Litovchick, Wenqi Wang, Junjie Chen, Bingliang Fang, and Jae-Il Park
Molecular Cell 2021 Feb 17;S1097-2765(21)00087-3, doi: 10.1016/j.molcel.2021.02.001, PMID: 33626321, PMC8052288. Supplementary Information (PDF)
TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis
Youn-Sang Jung, Sabrina Stratton, Sung Ho Lee, Moon Jong Kim, Sohee Jun, Jie Zhang, Biyun Zheng, Michelle C. Barton, Jae-Il Park
Hepatology 2021 Feb;73(2):776-794. doi: 10.1002/hep.31305. Epub 2020 Nov 17. PMID: 32380568; PMCID: PMC7062731. Supplementary Information (PDF)
Xi Shen, Rui Wang, Moon Jong Kim, Qianghua Hu, Chih-Chao Hsu, Jun Yao, Naeh Klages-Mundt, Yanyan Tian, Erica Lynn, Thomas F. Brewer, Yilei Zhang, Banu Arun, Boyi Gan, Michael Andreeff, Shunichi Takeda, Junjie Chen, Jae-il Park, Xiaobing Shi, Christopher J. Chang, Sung Yun Jung, Jun Qin, Lei Li
Molecular Cell 2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. PubMed PMID: 33338401.
Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
Moon Jong Kim,* YuanJian Huang,* Jae-Il Park
Cancers (Basel) 2020 Dec 4;12(12). doi: 10.3390/cancers12123638. PubMed PMID: 33291655.
Blockers of Wnt3a, Wnt10a or β-catenin prevent chemotherapy-induced neuropathic pain in vivo
Hee Kee Kim, Jingi Bae, Sung Ho Lee, Seon-Hee Hwang, Min-Sik Kim, Moon Jong Kim, Sohee Jun, Chris L. Cervantes, Youn-Sang Jung, Seunghoon Back, Hangyeore Lee, Seung-Eun Lee, Patrick M Dougherty, Sang-Won Lee, Jae-Il Park, Salahadin Abdi
Neurotherapeutics 2020 Oct 30. PMID: 33128175; DOI: 10.1007/s13311-020-00956-w
Wnt Signaling in Cancer: Therapeutic Targeting of Wnt Signaling beyond β-Catenin and Destruction Complex
Youn-Sang Jung, Jae-Il Park
Experimental Molecular Medicine 2020 Feb 10;. doi: 10.1038/s12276-020-0380-6. PMID: 32037398, PMCID: PMC7062731
LncGata6-Controlled Stemness in Regeneration and Cancer
Youn-Sang Jung,* Moon Jong Kim,* Jae-Il Park
Non-coding RNA Investig pii: 4. doi: 10.21037/ncri.2019.01.02., 1/2019, PMCID: PMC6377203
TMEM9 Promotes Intestinal Tumorigenesis via v-ATPase-Activated Wnt/β-Catenin Signaling
Youn-Sang Jung,* Sohee Jun,* Moon Jong Kim, Sung Ho Lee, Han Na Suh, Esther M. Lien, Hae-Yun Jung, Sunhye Lee, Jie Zhang, Jung-In Yang, Hong Ji, Ji Yuan Wu, Wenqi Wang, Rachel K. Miller, Junjie Chen, Pierre D. McCrea, Scott Kopetz, Jae-Il Park
Nature Cell Biology 20, 1421-1433, 12/2018, PMCID: PMC6261670. Supplementary Information (PDF)
PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis
Moon Jong Kim, Xia Bo, Han Na Suh, Sung Ho Lee, Sohee Jun, Esther M. Lien, Jie Zhang, Kaifu Chen, Jae-Il Park
Developmental Cell 44, 582-596, 3/2018 PMCID: PMC5854208. Supplementary Information (PDF)
Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration
Han Na Suh, Moon Jong Kim, Youn-Sang Jung, Esther M. Lien, Sohee Jun, Jae-Il Park
Cell Reports 21, 2571-2584 11/2017 PMCID: PMC5726811. Supplementary Information (PDF)
Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia
Suh HN,* Jun S,* Oh AY, Srivastava M, Lee S, Taniguchi CM, Zhang S, Lee WS, Chen J, Park BJ, Park JI
Scientific Reports 6:38273, 12/2016. e-Pub 12/2016. PMCID: PMC5138641
LIG4 mediates Wnt signalling-induced radioresistance
Jun S,* Jung YS,* Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI
Nature Communications 7:10994, 2016. e-Pub 3/2016. PMCID: PMC4820809
PAF-Wnt Signaling-Induced Cell Plasticity Is Required for Maintenance of Breast Cancer Cell Stemness
Wang X,* Jung YS,* Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI
Nature Communications doi:10.1038/ncomms10633:10633, 2016. e-Pub 2/2016. PMCID: PMC4743006
Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
Jung YS, Jun S, Lee SH, Sharma A, Park JI
Oncotarget 6(35)(35):37257-68, 11/2015. e-Pub 10/2015. PMCID: PMC4741928.
PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation
Jung HY, Jun S, Lee M, Kim HC, Wang X, Ji H, McCrea PD, Park JI
Molecular Cell 52(2):193-205, 10/2013. e-Pub 9/2013. PMCID: PMC4040269
PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis
Jun S, Lee SH, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI
Cell Reports e-Pub 10/2013. PMCID: PMC4157353
FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus
Wang W, Li X, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J.
Developmental Cell 32(6):707-18, 3/2015. PMCID: PMC4374128
P120-catenin regulates REST/CoREST, and modulates mouse embryonic stem cell differentiation
Lee M, Ji H, Furuta Y, Park JI, McCrea PD.
Journal of Cell Science 127(Pt 18):4037-51, 9/2014. e-Pub 7/2014. PMCID: PMC4163646
HIV-1 Vpr Inhibits Telomerase Activity Via EDD-DDB1-VPRB3 E3 Ligase Complex
Wang X, Singh S, Jung HY, Yang G, Jun S, Sastry KJ, Park JI.
Journal of Biological Chemistry 288(22):15474-80, 5/2013. e-Pub 4/2013. PMCID: PMC3668709
Dyrk2-Associated EDD-DDB1-VprBP E3 Ligase Inhibits Telomerase by TERT Degradation
Jung HY, Wang X, Jun S, Park JI.
Journal of Biological Chemistry 288(10):7252-62, 3/2013. e-Pub 1/2013. PMCID: PMC3591633
Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway
Hong JY, Park JI, Lee M, Muñoz WA, Miller RK, Ji H, Gu D, Ezan J, Sokol SY, McCrea PD.
Journal of Cell Science 125(Pt 3):561-9, 2/2012. PMCID: PMC3367828
PTPN14 is required for the density-dependent control of YAP1
Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J.
Genes and Development 26(17):1959-71, 9/2012. PMCID: PMC3435498
Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members
Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD.
Journal of Cell Science 123(Pt 24):4351-4365, 12/2010. e-Pub 11/2010. PMCID: PMC2995616
Telomerase modulates Wnt signalling by association with target gene chromatin
Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE.
Nature 460 (7251):66-72, 7/2009. PMCID: PMC4349391
Nature Reviews Genetics Highlights
Requirement of Wnt/beta-catenin signaling in pronephric kidney development
Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD.
Mechanisms of Development e-Pub 12/2008. PMCID: PMC2684468. 126(3-4):142-59, 3/2009.
Developmental functions of the P120-catenin sub-family
McCrea PD, Park JI.
Biochimica et Biophysica Acta 2007; 1773(1):17-33. PMID: 16942809
Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals
Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD.
Developmental Cell 11(5):683-95, 11/2006. PMID: 17084360.
Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets
Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD.
Developmental Cell 8(6):843-54, 6/2005. PMID: 15935774.
Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin
Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM, McCrea PD.
Nature Cell Biology 6(12):1212-20, 12/2004. e-Pub 11/2004. PMID: 15543138.
Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac
Fang X, Ji H, Kim SW, Park JI, Vaught TG, Anastasiadis PZ, Ciesiolka M, McCrea PD.
Journal of Cell Biology 165(1):87-98, 4/2004. e-Pub 4/2004. PMCID: PMC2172091.
Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways
Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG.
Oncogene 22(28):4314-32, 7/2003. PMID: 12853969.
Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma
Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, Kim HJ, Chi SG.
International Journal of Cancer 104(3):318-27, 4/2003. PMID: 12569555.
Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer
Park BJ, Park JI, Byun DS, Park JH, Chi SG.
Cancer Research 60(11):3031-8, 6/2000. PMID: 10850453.
Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma
Kang MJ, Park BJ, Byun DS, Park JI, Kim HJ, Park JH, Chi SG.
Clinical Cancer Research 6(5):1767-71, 5/2000. PMID: 10815895.
*Equally contributed authors.