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PCLAF-DREAM drives alveolar cell plasticity for lung regeneration

Bongjun Kim, Yuanjian Huang, Kyung-Pil Ko, Shengzhe Zhang, Gengyi Zou, Jie Zhang, Moonjong Kim, Danielle Little, Lisandra Vila Ellis, Margherita Paschini, Sohee Jun, Kwon-Sik Park, Jichao Chen, Carla Kim, Jae-Il Park


In revision

Cell plasticity, changes in cell fate, is essential for tissue regeneration. In the lung, failure of regeneration leads to diseases, including fibrosis. However, the mechanisms governing alveolar cell plasticity during lung repair remain elusive. The dimerization partner, RB-like, E2F, and multi-vulval class B (DREAM) complex regulates cell quiescence and proliferation depending on its binding partners. We previously showed that PCNA clamp-associated factor (PCLAF) remodels the DREAM complex, shifting the balance from cell quiescence towards cell proliferation. Here, we found that PCLAF expression is specific to proliferating lung progenitor cells, along with the DREAM target genes by lung injury. Genetic ablation of Pclaf impaired alveolar type I (AT1) cell regeneration from alveolar type II (AT2) cells, leading to lung fibrosis. Mechanistically, the PCLAF-DREAM complex transactivates CLIC4, triggering TGF-b signaling, which promotes AT1 cell generation from AT2 cells. Furthermore, a drug candidate that mimics the PCLAF-DREAM transcriptional signature increases AT2 cell plasticity, preventing lung fibrosis in organoids and mice. Our study reveals the unexpected role of the PCLAF-DREAM axis in promoting alveolar cell plasticity, beyond cell proliferation control, proposing a potential therapeutic avenue for lung fibrosis prevention.


CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma

Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Youn-Sang Jung, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Kwon-Sik Park, Jae-Il Park

Cell Reports 2024 May 25; 43(6):114286. doi: 10.1016/j.celrep.2024.114286. PMID: 38796854; NIHMSID:NIHMS1997795

Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, some lung adenocarcinoma (LUAD) cells transform into neuroendocrine (NE) tumor cells. However, the mechanisms of NE cell plasticity remain unclear. CRACD, a capping protein inhibitor, is frequently inactivated in cancers. CRACD knock-out (KO) is sufficient to de-repress NE-related gene expression in the pulmonary epithelium and LUAD cells. In LUAD mouse models, Cracd KO increases intratumoral heterogeneity with NE gene expression. Single-cell transcriptomic analysis showed that Cracd KO-induced NE cell plasticity is associated with cell de-differentiation and stemness-related pathway activation. The single-cell transcriptomic analysis of LUAD patient tumors recapitulates that the distinct LUAD NE cell cluster expressing NE genes is co-enriched with impaired actin remodeling. This study reveals the crucial role of CRACD in restricting NE cell plasticity that induces cell de-differentiation, providing new insights into the cell plasticity of LUAD.

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Tumor niche network-defined subtypes predict immunotherapy response of esophageal squamous cell cancer

Kyung-Pil Ko, Shengzhe Zhang, Yuanjian Huang, Bongjun Kim, Gengyi Zou, Sohee Jun, Jie Zhang, Cecilia Martin, Karen J. Dunbar, Gizem Efe, Anil K. Rustgi, Haiyang Zhang, Hiroshi Nakagawa, Jae-Il Park

iScience 2024 April 22;27(5):109795. doi: 10.1016/j.isci.2024.109795. PMID: 38741711, PMCID: PMC11089351

Despite the promising outcome of immune checkpoint blockade (ICB), ICB resistance is a new challenge. Thus, selecting patients for specific ICB applications is crucial for maximizing therapeutic efficacy. Herein we curated 69 human esophageal squamous cell cancer (ESCC) patients’ tumor microenvironment (TME) single-cell transcriptomic datasets for ESCC subtyping. Notably, integrative analyses of the cellular network transcriptional signatures of T cells, myeloid cells, and fibroblasts define distinct ESCC subtypes characterized by T cell exhaustion, Interferon alpha and beta signaling, TIGIT enrichment, and specific marker genes. Furthermore, this approach classifies ESCC patients into ICB responders and non-responders, validated by liquid biopsy single-cell transcriptomics. This study stratifies ESCC patients by TME transcriptional network, which provides a novel insight into tumor niche remodeling and helps predict ICB responses of ESCC patients.

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E-cadherin loss promotes diffuse-type gastric cancer tumorigenesis via EZH2-mediated reprogramming

Gengyi Zou*, Yuanjian Huang*, Shengzhe Zhang, Kyung-Pil Ko, Bong Jun Kim, Jie Zhang, Vishwa Venkatesan, Melissa P. Pizzi, Yibo Fan, Sohee Jun, Na Niu, Huamin Wang, Shumei Song, Jaffer A. Ajani, Jae-Il Park

Journal of Experimental Medicine  2024 Feb; 221 (4): e20230561.

PMID: 38411616, PMCID: PMC10899090

Diffuse-type gastric adenocarcinoma (DGAC) is a deadly cancer often diagnosed late and resistant to treatment. While hereditary DGAC is linked to CDH1 mutations, the role of CDH1/E-cadherin inactivation in sporadic DGAC tumorigenesis remains elusive. We discovered CDH1 inactivation in a subset of DGAC patient tumors. Analyzing single-cell transcriptomes in malignant ascites, we identified two DGAC subtypes: DGAC1 (CDH1 loss) and DGAC2 (lacking immune response). DGAC1 displayed distinct molecular signatures, activated DGAC-related pathways, and an abundance of exhausted T cells in ascites. Genetically engineered murine gastric organoids showed that Cdh1 knock-out (KO), KrasG12D, Trp53 KO (EKP) accelerates tumorigenesis with immune evasion compared to KrasG12D, Trp53 KO (KP). We also identified EZH2 as a key mediator promoting CDH1 loss-associated DGAC tumorigenesis. These findings highlight DGAC's molecular diversity and potential for personalized treatment in CDH1-inactivated patients.


Key genetic determinants driving esophageal squamous cell carcinoma initiation and immune evasion

Kyung-Pil Ko, Yuanjian Huang, Shengzhe Zhang, Gengyi Zou, Bongjun Kim, Jie Zhang, Sohee Jun, Cecilia Martin, Karen J. Dunbar, Gizem Efe, Anil K. Rustgi, Hiroshi Nakagawa, Jae-Il Park

Gastroenterology 2023 Sep;165(3) PMID: 37257519, PMCID: PMC10527250

Background and aims: Despite recent progress in identifying aberrant genetic and epigenetic alterations in esophageal squamous cell carcinoma (ESCC), the mechanism of ESCC initiation remains unknown. Methods: Using CRISPR/Cas 9-based genetic ablation, we targeted 9 genes (TP53, CDKN2A, NOTCH1, NOTCH3, KMT2D, KMT2C, FAT1, FAT4, and AJUBA) in murine esophageal organoids (EOs). Transcriptomic phenotypes of organoids and chemokine released by organoids were analyzed by single-cell RNA sequencing (scRNA-seq). Tumorigenicity of organoids and tumor-infiltrated immune cells were monitored by allograft transplantation. Human ESCC scRNA-seq datasets were analyzed to classify patients and find subsets relevant to organoid models and immune evasion. Results: We established 32 genetically engineered EOs and identified key genetic determinants that drive ESCC initiation. A single-cell transcriptomic analysis uncovered that Trp53, Cdkn2a, and Notch1 (PCN) triple knockout (KO) induces neoplastic features of ESCC by generating cell lineage heterogeneity and high cell plasticity. PCN KO also generates immunosuppressive niche enriched with exhausted T cells and M2 macrophages via the CCL2-CCR2 axis. Mechanistically, CDKN2A inactivation transactivates CCL2 via NF-B. Moreover, comparative single-cell transcriptomic analyses stratified ESCC patients and identified a specific subtype recapitulating the PCN-type ESCC signatures, including the high expression of CCL2 and CD274/PD-L1. Conclusions: Our study unveils that loss of TP53, CDKN2A, and NOTCH1 induces esophageal neoplasia and immune evasion for ESCC initiation and proposes the CCL2 blockade as a viable approach to target PCN-type ESCC.


Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis

Shengzhe Zhang, Sung Ho Lee, Litong Nie, Yuanjian Huang, Gengyi Zou, Youn-sang Jung, Sohee Jun, Jie Zhang, Esther M. Lien, Junjie Chen, Jae-Il Park

Cancer Communications 2023 Jan;43(1):159-163. PMID: 36336962, PMCID: PMC9859727

DOI: 10.1002/cac2.12382

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Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer

Yuanjian Huang,* Shengzhe Zhang,* Jae-Il Park

In: Kloc, M., Kubiak, J.Z. (eds) Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Results and Problems in Cell Differentiation, vol 70. Springer, Cham. (PDF) PMID: 36348125 PMCID: PMC9677682

Actin is a highly conserved protein in mammals. The actin dynamics is regulated by actin-binding proteins and actin-related proteins. Nuclear actin and these regulatory proteins participate in multiple nuclear processes, including chromosome architecture organization, chromatin remodeling, transcription machinery regulation, and DNA repair. It is well known that the dysfunctions of these processes contribute to the development of cancer. Moreover, emerging evidence has shown that the deregulated actin dynamics is also related to cancer. This chapter discusses how the deregulation of nuclear actin dynamics contributes to tumorigenesis via such various nuclear events.



WNT5A-RHOA signaling is a driver of tumorigenesis and represents a therapeutically actionable vulnerability in small cell lung cancer

Kee-Beom Kim, Dong-Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bongjun Kim, Bingliang Fang, Jae-Il Park, Yi Zheng, Kwon-Sik Park

Cancer Research  14 Sep 2022, CAN-22-1170. doi: 10.1158/0008-5472.CAN-22-1170

PMID: 36102736 PMCID: PMC9669186

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WNT Signaling in Liver Regeneration, Disease, and Cancer

Gengyi Zou and Jae-Il Park

Clin Mol Hepatol 2022 Jul 4;. doi: 10.3350/cmh.2022.0058. PMID: 35785913

Full-text (PDF)

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Establishing Transgenic Murine Esophageal Organoids

Kyung-Pil Ko, Jie Zhang, Jae-Il Park

STAR Protocols  Volume 3, Issue 2, 17 June 2022, 101317,

PMID: 35496812, PMCID: PMC9048136

Full-text (PDF)




KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small-cell lung cancer

Kee-Beom Kim, Ashish Kabra, Dong-Wook Kim, Yongming Xue, Yuanjian Huang, Pei-Chi Hou, Yunpeng Zhou, Leilani J. Miranda, Jae-Il Park, Xiaobing Shi, Timothy P. Bender, John H. Bush welder, Kwon-Sik Park

Science Advances   2022 Feb 18;8(7):eabl4618. doi: 10.1126/sciadv.abl4618. Epub 2022 Feb 16, PMID: 35171684

Full-text (PDF)

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A New Murine Esophageal Organoid Culture Method and Organoid-Based Model of Esophageal Squamous Cell Neoplasia

Biyun Zheng,* Kyung-Pil Ko,* Xuefen Fang, Xiaozhong Wang, Jie Zhang, Sohee Jun, Bong-Jun Kim, Wenyi Luo, Moon Jong Kim, Youn-Sang Jung, Christopher L. Cervantes, Jae-Il Park

iScience   2021 Nov 15; 103440, DOI:, PMID: 34877497, PMC8633967. 

scRNA-seq data (GSE174577)

Supplemental Information (PDF)

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Yap/Taz-Activated Tert-Expressing Acinar Cells Are Required for Pancreatic Regeneration

Han Na Suh, Moon Jong Kim, Sung Ho Lee, Sohee Jun, Jie Zhang, Randy L Johnson, and Jae-Il Park

BioRxiv   BioRxiv 2021 Sep; doi:

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PAF Remodels the DREAM Complex to Bypass Cell Quiescence and Promote Lung Tumorigenesis 

Moon Jong Kim, Christopher Cervantes, Youn-Sang Jung, Xiaoshan Zhang, Jie Zhang, Sung Ho Lee, Sohee Jun, Larisa Litovchick, Wenqi Wang, Junjie Chen, Bingliang Fang, and Jae-Il Park

Molecular Cell   2021 Feb 17;S1097-2765(21)00087-3, doi: 10.1016/j.molcel.2021.02.001, PMID: 33626321, PMC8052288.     Supplementary Information (PDF)

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TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis

Youn-Sang Jung, Sabrina Stratton, Sung Ho Lee, Moon Jong Kim, Sohee Jun, Jie Zhang, Biyun Zheng, Michelle C. Barton, Jae-Il Park

Hepatology   2021 Feb;73(2):776-794. doi: 10.1002/hep.31305. Epub 2020 Nov 17. PMID: 32380568; PMCID: PMC7062731.     Supplementary Information (PDF)

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A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia

Xi Shen, Rui Wang, Moon Jong Kim, Qianghua Hu, Chih-Chao Hsu, Jun Yao, Naeh Klages-Mundt, Yanyan Tian, Erica Lynn, Thomas F. Brewer, Yilei Zhang, Banu Arun, Boyi Gan, Michael Andreeff, Shunichi Takeda, Junjie Chen, Jae-il Park, Xiaobing Shi, Christopher J. Chang, Sung Yun Jung, Jun Qin, Lei Li

Molecular Cell   2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. PubMed PMID: 33338401.

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Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views

Moon Jong Kim,* YuanJian Huang,* Jae-Il Park

Cancers (Basel)   2020 Dec 4;12(12). doi: 10.3390/cancers12123638. PubMed PMID: 33291655.

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Blockers of Wnt3a, Wnt10a or β-catenin prevent chemotherapy-induced neuropathic pain in vivo

Hee Kee Kim, Jingi Bae, Sung Ho Lee, Seon-Hee Hwang, Min-Sik Kim, Moon Jong Kim, Sohee Jun, Chris L. Cervantes, Youn-Sang Jung, Seunghoon Back, Hangyeore Lee, Seung-Eun Lee, Patrick M Dougherty, Sang-Won Lee, Jae-Il Park, Salahadin Abdi

Neurotherapeutics   2020 Oct 30. PMID: 33128175; DOI: 10.1007/s13311-020-00956-w

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Wnt Signaling in Cancer: Therapeutic Targeting of Wnt Signaling beyond β-Catenin and Destruction Complex 

Youn-Sang Jung, Jae-Il Park

Experimental Molecular Medicine   2020 Feb 10;. doi: 10.1038/s12276-020-0380-6. PMID: 32037398, PMCID: PMC7062731

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LncGata6-Controlled Stemness in Regeneration and Cancer

Youn-Sang Jung,* Moon Jong Kim,* Jae-Il Park  

Non-coding RNA Investig   pii: 4. doi: 10.21037/ncri.2019.01.02., 1/2019, PMCID: PMC6377203

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TMEM9 Promotes Intestinal Tumorigenesis via v-ATPase-Activated Wnt/β-Catenin Signaling 

Youn-Sang Jung,* Sohee Jun,* Moon Jong Kim, Sung Ho Lee, Han Na Suh, Esther M. Lien, Hae-Yun Jung, Sunhye Lee, Jie Zhang, Jung-In Yang, Hong Ji, Ji Yuan Wu, Wenqi Wang, Rachel K. Miller, Junjie Chen, Pierre D. McCrea, Scott Kopetz, Jae-Il Park 

Nature Cell Biology   20, 1421-1433, 12/2018, PMCID: PMC6261670.   Supplementary Information (PDF)

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PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis

Moon Jong Kim, Xia Bo, Han Na Suh, Sung Ho Lee, Sohee Jun, Esther M. Lien, Jie Zhang, Kaifu Chen, Jae-Il Park     

Developmental Cell   44, 582-596, 3/2018  PMCID: PMC5854208.   Supplementary Information (PDF)

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Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration

Han Na Suh, Moon Jong Kim, Youn-Sang Jung, Esther M. Lien, Sohee Jun, Jae-Il Park

Cell Reports   21, 2571-2584 11/2017  PMCID: PMC5726811.     Supplementary Information (PDF)

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Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia

Suh HN,* Jun S,* Oh AY, Srivastava M, Lee S, Taniguchi CM, Zhang S, Lee WS, Chen J, Park BJ, Park JI

Scientific Reports  6:38273, 12/2016.  e-Pub 12/2016. PMCID: PMC5138641

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LIG4 mediates Wnt signalling-induced radioresistance  

Jun S,* Jung YS,* Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI

Nature Communications  7:10994, 2016.  e-Pub 3/2016. PMCID: PMC4820809

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PAF-Wnt Signaling-Induced Cell Plasticity Is Required for Maintenance of Breast Cancer Cell Stemness 

Wang X,* Jung YS,* Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI   

Nature Communications   doi:10.1038/ncomms10633:10633, 2016.  e-Pub 2/2016. PMCID: PMC4743006

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Wnt2 complements Wnt/β-catenin signaling in colorectal cancer 

Jung YS, Jun S, Lee SH, Sharma A, Park JI

Oncotarget   6(35)(35):37257-68, 11/2015. e-Pub 10/2015. PMCID: PMC4741928.

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PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation 

Jung HY, Jun S, Lee M, Kim HC, Wang X, Ji H, McCrea PD, Park JI

Molecular Cell   52(2):193-205, 10/2013. e-Pub 9/2013. PMCID: PMC4040269    

Molecular Cell Preview

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PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis 

Jun S, Lee SH, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI

Cell Reports   e-Pub 10/2013. PMCID: PMC4157353

FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus 

Wang W, Li X, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J.

Developmental Cell   32(6):707-18, 3/2015. PMCID: PMC4374128

P120-catenin regulates REST/CoREST, and modulates mouse embryonic stem cell differentiation 

Lee M, Ji H, Furuta Y, Park JI, McCrea PD.

Journal of Cell Science  127(Pt 18):4037-51, 9/2014. e-Pub 7/2014. PMCID: PMC4163646

HIV-1 Vpr Inhibits Telomerase Activity Via EDD-DDB1-VPRB3 E3 Ligase Complex 

Wang X, Singh S, Jung HY, Yang G, Jun S, Sastry KJ, Park JI.

Journal of Biological Chemistry  288(22):15474-80, 5/2013. e-Pub 4/2013. PMCID: PMC3668709


Dyrk2-Associated EDD-DDB1-VprBP E3 Ligase Inhibits Telomerase by TERT Degradation 

Jung HY, Wang X, Jun S, Park JI.

Journal of Biological Chemistry   288(10):7252-62, 3/2013. e-Pub 1/2013. PMCID: PMC3591633


Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway 

Hong JY, Park JI, Lee M, Muñoz WA, Miller RK, Ji H, Gu D, Ezan J, Sokol SY, McCrea PD.

Journal of Cell Science   125(Pt 3):561-9, 2/2012. PMCID: PMC3367828


PTPN14 is required for the density-dependent control of YAP1 

Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J.

Genes and Development   26(17):1959-71, 9/2012. PMCID: PMC3435498


Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members 

Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD.

Journal of Cell Science   123(Pt 24):4351-4365, 12/2010. e-Pub 11/2010. PMCID: PMC2995616


Telomerase modulates Wnt signalling by association with target gene chromatin   

Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE.

Nature   460 (7251):66-72, 7/2009.   PMCID: PMC4349391

Nature News and Views 

Nature Reviews Genetics Highlights 


Requirement of Wnt/beta-catenin signaling in pronephric kidney development  

Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD.

Mechanisms of Development   e-Pub 12/2008. PMCID: PMC2684468. 126(3-4):142-59, 3/2009.


Developmental functions of the P120-catenin sub-family

McCrea PD, Park JI.

Biochimica et Biophysica Acta   2007; 1773(1):17-33. PMID: 16942809


Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals

Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD.

Developmental Cell   11(5):683-95, 11/2006. PMID: 17084360.


Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets 

Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD.

Developmental Cell   8(6):843-54, 6/2005. PMID: 15935774.

Developmental Cell Preview

Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin 

Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM, McCrea PD.

Nature Cell Biology    6(12):1212-20, 12/2004.  e-Pub 11/2004. PMID: 15543138.



Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac 

Fang X, Ji H, Kim SW, Park JI, Vaught TG, Anastasiadis PZ, Ciesiolka M, McCrea PD.

Journal of Cell Biology   165(1):87-98, 4/2004. e-Pub 4/2004. PMCID: PMC2172091.


Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways 

Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG.

Oncogene   22(28):4314-32, 7/2003. PMID: 12853969.


Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma 

Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, Kim HJ, Chi SG.

International Journal of Cancer   104(3):318-27, 4/2003. PMID: 12569555.


Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer

Park BJ, Park JI, Byun DS, Park JH, Chi SG.

Cancer Research   60(11):3031-8, 6/2000. PMID: 10850453.


Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma 

Kang MJ, Park BJ, Byun DS, Park JI, Kim HJ, Park JH, Chi SG.

Clinical Cancer Research   6(5):1767-71, 5/2000. PMID: 10815895.



*Equally contributed authors.


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