Moon Jong Kim, Christopher Cervantes, Youn-Sang Jung, Xiaoshan Zhang, Jie Zhang, Sung Ho Lee, Sohee Jun, Larisa Litovchick, Wenqi Wang, Junjie Chen, Bingliang Fang, and Jae-Il Park

PAF Remodels the DREAM Complex to Bypass Cell Quiescence and Promote Lung Tumorigenesis 

Molecular Cell  2021 Feb 17;S1097-2765(21)00087-3, doi: 10.1016/j.molcel.2021.02.001, PMID: 33626321, PDF

Xi Shen, Rui Wang, Moon Jong Kim, Qianghua Hu, Chih-Chao Hsu, Jun Yao, Naeh Klages-Mundt, Yanyan Tian, Erica Lynn, Thomas F. Brewer, Yilei Zhang, Banu Arun, Boyi Gan, Michael Andreeff, Shunichi Takeda, Junjie Chen, Jae-il Park, Xiaobing Shi, Christopher J. Chang, Sung Yun Jung, Jun Qin, Lei Li

A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia

Molecular Cell  80, 1013-1024, Dec 17, 2020, doi: 10.1016/j.molcel.2020.11.040

Moon Jong Kim,* YuanJian Huang,* Jae-Il Park

Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views

Cancers (Basel)  2020 Dec 4;12(12). doi: 10.3390/cancers12123638. PubMed PMID: 33291655.

Hee Kee Kim, Jingi Bae, Sung Ho Lee, Seon-Hee Hwang, Min-Sik Kim, Moon Jong Kim, Sohee Jun, Chris L. Cervantes, Youn-Sang Jung, Seunghoon Back, Hangyeore Lee, Seung-Eun Lee, Patrick M Dougherty, Sang-Won Lee, Jae-Il Park, Salahadin Abdi

Blockers of Wnt3a, Wnt10a or β-catenin prevent chemotherapy-induced neuropathic pain in vivo

Neurotherapeutics   2020 Oct 30. PMID: 33128175; DOI: 10.1007/s13311-020-00956-w

Youn-Sang Jung, Sabrina Stratton, Sung Ho Lee, Moon Jong Kim, Sohee Jun, Jie Zhang, Biyun Zheng, Michelle C. Barton, Jae-Il Park

TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis  

Hepatology  2020 May 7. doi: 10.1002/hep.31305. PMID: 32380568, PMCID: PMC7062731

Youn-Sang Jung, Jae-Il Park

Wnt Signaling in Cancer: Therapeutic Targeting of Wnt Signaling beyond β-Catenin and Destruction Complex. 

Experimental Molecular Medicine  2020 Feb 10;. doi: 10.1038/s12276-020-0380-6. PMID: 32037398, PMCID: PMC7062731

Youn-Sang Jung,* Moon Jong Kim,* Jae-Il Park  

LncGata6-Controlled Stemness in Regeneration and Cancer.

Non-coding RNA Investig  pii: 4. doi: 10.21037/ncri.2019.01.02., 1/2019, PMCID: PMC6377203


Youn-Sang Jung,* Sohee Jun,* Moon Jong Kim, Sung Ho Lee, Han Na Suh, Esther M. Lien, Hae-Yun Jung, Sunhye Lee, Jie Zhang, Jung-In Yang, Hong Ji, Ji Yuan Wu, Wenqi Wang, Rachel K. Miller, Junjie Chen, Pierre D. McCrea, Scott Kopetz, Jae-Il Park 

TMEM9 Promotes Intestinal Tumorigenesis via v-ATPase-Activated Wnt/β-Catenin Signaling

Nature Cell Biology  20, 1421-1433, 12/2018, PMCID: PMC6261670


Youn-Sang Jung, Wenqi Wang, Sohee Jun, Jie Zhang, Mrinal Srivastava, Moon Jong Kim, Esther M. Lien, Joan Shang, Junjie Chen, Pierre D. McCrea, Songlin Zhang, Jae-Il Park

Deregulation of CRAD-Controlled Cytoskeleton Initiates Mucinous Colorectal Cancer via β-Catenin

Nature Cell Biology  20, 1303-1314, 11/2018, PMCID: PMC6261439; Highlighted in News & Views


Moon Jong Kim, Xia Bo, Han Na Suh, Sung Ho Lee, Sohee Jun, Esther M. Lien, Jie Zhang, Kaifu Chen, Jae-Il Park     

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis. 

Developmental Cell  44, 582-596, 3/2018  PMCID: PMC5854208


Han Na Suh, Moon Jong Kim, Youn-Sang Jung, Esther M. Lien, Sohee Jun, Jae-Il Park

Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration.

Cell Reports  21, 2571-2584 11/2017  PMCID: PMC5726811


Suh HN,* Jun S,* Oh AY, Srivastava M, Lee S, Taniguchi CM, Zhang S, Lee WS, Chen J, Park BJ, Park JI

Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia. 

Scientific Reports 6:38273, 12/2016.  e-Pub 12/2016. PMCID: PMC5138641


Jun S,* Jung YS,* Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI.

LIG4 mediates Wnt signalling-induced radioresistance.  

Nature Communications 7:10994, 2016.  e-Pub 3/2016. PMCID: PMC4820809


Wang X,* Jung YS,* Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI.   

PAF-Wnt Signaling-Induced Cell Plasticity Is Required for Maintenance of Breast Cancer Cell Stemness 

Nature Communications  doi:10.1038/ncomms10633:10633, 2016.  e-Pub 2/2016. PMCID: PMC4743006


Jung YS, Jun S, Lee SH, Sharma A, Park JI.

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer. 

Oncotarget 6(35)(35):37257-68, 11/2015. e-Pub 10/2015. PMCID: PMC4741928.


Wang W, Li X, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J. FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus. 

Developmental Cell 32(6):707-18, 3/2015. PMCID: PMC4374128


Lee M, Ji H, Furuta Y, Park JI, McCrea PD.

P120-catenin regulates REST/CoREST, and modulates mouse embryonic stem cell differentiation. 

Journal of Cell Science 127(Pt 18):4037-51, 9/2014. e-Pub 7/2014. PMCID: PMC4163646


Jung HY, Jun S, Lee M, Kim HC, Wang X, Ji H, McCrea PD, Park JI.

PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation. 

Molecular Cell  52(2):193-205, 10/2013. e-Pub 9/2013. PMCID: PMC4040269    Previews


Jun S, Lee SH, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI. PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis. 

Cell Reports  e-Pub 10/2013. PMCID: PMC4157353


Wang X, Singh S, Jung HY, Yang G, Jun S, Sastry KJ, Park JI.

HIV-1 Vpr Inhibits Telomerase Activity Via EDD-DDB1-VPRB3 E3 Ligase Complex. 

Journal of Biological Chemistry 288(22):15474-80, 5/2013. e-Pub 4/2013. PMCID: PMC3668709


Jung HY, Wang X, Jun S, Park JI.

Dyrk2-Associated EDD-DDB1-VprBP E3 Ligase Inhibits Telomerase by TERT Degradation. 

Journal of Biological Chemistry 288(10):7252-62, 3/2013. e-Pub 1/2013. PMCID: PMC3591633


Hong JY, Park JI, Lee M, Muñoz WA, Miller RK, Ji H, Gu D, Ezan J, Sokol SY, McCrea PD.

Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway. 

Journal of Cell Science 125(Pt 3):561-9, 2/2012. PMCID: PMC3367828


Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J.

PTPN14 is required for the density-dependent control of YAP1. 

Genes and Development 26(17):1959-71, 9/2012. PMCID: PMC3435498


Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD.

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. 

Journal of Cell Science 123(Pt 24):4351-4365, 12/2010. e-Pub 11/2010. PMCID: PMC2995616


Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE.

Telomerase modulates Wnt signalling by association with target gene chromatin.   

Nature 460 (7251):66-72, 7/2009. (Nature News and Views) (Nature Reviews Genetics Highlights) PMCID: PMC4349391


Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD.

Requirement of Wnt/beta-catenin signaling in pronephric kidney development. 

Mechanisms of Development e-Pub 12/2008. PMCID: PMC2684468. 126(3-4):142-59, 3/2009.


McCrea PD, Park JI.

Developmental functions of the P120-catenin sub-family.

Biochimica et Biophysica Acta 2007; 1773(1):17-33. PMID: 16942809


Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD.

Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals. 

Developmental Cell 11(5):683-95, 11/2006. PMID: 17084360.


Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD.

Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. 

Developmental Cell 8(6):843-54, 6/2005. (Previews) PMID: 15935774.


Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM, McCrea PD.

Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. 

Nature Cell Biology 6(12):1212-20, 12/2004.  e-Pub 11/2004. PMID: 15543138.


Fang X, Ji H, Kim SW, Park JI, Vaught TG, Anastasiadis PZ, Ciesiolka M, McCrea PD.

Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac. 

Journal of Cell Biology 165(1):87-98, 4/2004. e-Pub 4/2004. PMCID: PMC2172091.


Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG.

Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways. 

Oncogene 22(28):4314-32, 7/2003. PMID: 12853969.


Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, Kim HJ, Chi SG.

Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma. 

International Journal of Cancer 104(3):318-27, 4/2003. PMID: 12569555.


Park BJ, Park JI, Byun DS, Park JH, Chi SG.

Mitogenic conversion of transforming growth factor-beta1 effect by oncogenic Ha-Ras-induced activation of the mitogen-activated protein kinase signaling pathway in human prostate cancer. 

Cancer Research 60(11):3031-8, 6/2000. PMID: 10850453.


Kang MJ, Park BJ, Byun DS, Park JI, Kim HJ, Park JH, Chi SG.

Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma. 

Clinical Cancer Research 6(5):1767-71, 5/2000. PMID: 10815895.



*Equally contributed authors.