Organoids

Organoids also called 'mini-organs' mimic the physiologic and pathologic events such as tissue homeostasis, regeneration,  and tumorigenesis. 

 

We have been collecting stem and progenitor cells from the normal tissues and growing them in three- and two-dimensional culture dishes to establish the various organoids of the intestine, esophagus, stomach, and pancreas. With additional genetic manipulation using CRISPR and Cre-loxP systems, we are in the study of what controls tissue regeneration and how the normal cells become tumor/cancer cells.