Our laboratory is interested in the `modeling of human cancer using genetically engineered mouse models. Employing comprehensive approaches including in silico analyses, biochemistry, molecular biology, and cell biology, we are identifying several candidate genes as the molecular targets for cancer treatment. Beyond cell line experiments, we have established various mouse models mimicking the pathologic condition of tumor initiation, proliferation, metastasis, and suppression.
PDX (patient-derived xenograft) and PDO (patient-derived orgnaoids)
For better human relevance, we are also employing PDX and PDO systems.
Modeling of Mucinous Colorectal Cancer
Mucinous colorectal cancer (MC) is highly metastatic and therapeutically resistant. However, no mouse models for MC have been developed. Moreover, the underlying mechanisms of MC remain elusive. Recently, we established genetically engineered mouse models mimicking pathology of MC tumorigenesis (Jung et al., unpublished results).
Blockade of an amplifier of Wnt signaling represses colorectal cancer cell growth (human colorectal cancer patient-derived xenograft) (by Youn-Sang Jung).
Genetic ablation (knockout) of Wnt signaling amplifier inhibits the initiation of mammary tumors (MMTV-PyMT) in the mammary fat pad (by Sung-Ho Lee).
Suppression of lung tumorigenesis by knockout of the beta-catenin regulator (by Moon Jong Kim)