Modeling of Mucinous Colorectal Cancer

Mucinous colorectal cancer (MC) is highly metastatic and therapeutically resistant. However, no mouse models for MC have been developed. Moreover, the underlying mechanisms of MC remain elusive. Recently, we established genetically engineered mouse models mimicking pathology of MC tumorigenesis (Jung et al., unpublished results). 

Blockade of an amplifier of Wnt signaling represses colorectal cancer cell growth (human colorectal cancer patient-derived xenograft) (by Youn-Sang Jung).

Genetic ablation (knockout) of Wnt signaling amplifier inhibits the initiation of mammary tumors (MMTV-PyMT) in the mammary fat pad (by Sung-Ho Lee).

Suppression of lung tumorigenesis by knockout of the beta-catenin regulator (by Moon Jong Kim)