Park Laboratory

The overarching goal of our research program is to understand the biology of endoderm-derived tissues (esophagus, liver, stomach, and intestine) in the context of tissue homeostasis, regeneration, and cancer.

As model systems, we mainly utilize genetically engineered mice and organoids with a specific interest in Wnt signaling.

For research tools, we employ the hybrid approaches (single-cell transcriptomics and bioinformatics-driven cell biology and molecular biology). Here is an example of single-cell transcriptomics-based identification of root cells (cells of origin) of mucinous colorectal cancer by analyzing cell lineage trajectories.

Wnt signaling plays a critical role in governing various cellular processes during embryogenesis, organogenesis, and tissue homeostasis. Aberrant activation of Wnt signaling contributes to human diseases including cancer. However, given the crucial roles of Wnt signaling in tissue homeostasis and regeneration, direct targeting of Wnt signaling as a cancer treatment is still challenging. To overcome this, we have focused on identifying and investigating cancer-specific regulators of Wnt signaling. Employing comprehensive approaches including transcriptomics, genomics, and proteomics, we identified several candidate genes potentially modulating Wnt signaling specifically in cancer.

Our studies on several Wnt signaling regulators, including PAF (PCNA-associated factor)/KIAA0101/PCLAF, CRAD/KIAA1211/CRACD (Capping Protein Inhibiting Regulator of Actin Dynamics), TMEM9 (Transmembrane protein 9), and others also evolved into various research projects unveiling molecular and cellular targets for cancer therapy and tissue regeneration.