Park Laboratory
The overarching goal of our research program is to understand the mechanisms of tumorigenesis and tissue regeneration by employing genetically engineered mice and organoids. Our recent investigations have aimed to address two intriguing questions:
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Is cell plasticity a therapeutic vulnerability of cancer?
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Can manipulating cell plasticity promote tissue regeneration or prevent tissue damage?
Wnt signaling
WNT signaling is crucial for development, tissue homeostasis, and tissue regeneration. However, the deregulation of WNT signaling leads to human diseases, including cancer. We study how WNT signaling contributes to various pathophysiological processes.
Cell plasticity
A change in cell fate or phenotype is called cell plasticity. Tumor cell plasticity contributes to tumor progression, therapy resistance, relapse, and metastasis. We study the mechanisms of cellular plasticity and apply this knowledge to lay the foundation for developing cancer therapies. Fine control of cell dynamics also orchestrates tissue homeostasis and regeneration. Using organoids and animal models, we study the impact of cell plasticity manipulation on tissue regeneration.
Genetically engineered organoids and mice for disease modeling
3D cultured organoids mimic the pathophysiology of human diseases. We genetically manipulate organoids to model human diseases and dissect the mechanisms of disease development. Images: Genetically engineered gastric organoids