Organoids also called 'mini-organs' mimic the physiologic and pathologic events such as tissue homeostasis, regeneration, and tumorigenesis.
We have been collecting stem and progenitor cells from the normal tissues and growing them in three- and two-dimensional culture dishes to establish the various organoids of the intestine, esophagus, stomach, and pancreas. With additional genetic manipulation using CRISPR and Cre-loxP systems, we are in the study of what controls tissue regeneration and how the normal cells become tumor/cancer cells.
Esophagus organoids (by Biyun Zheng)
Stomach organoids (by Biyun Zheng)
Pancreatic organoid growth in the defined media (by SungHo Lee)
(by MoonJong Kim)
Intestinal crypt organoids
(by YounSang Jung)