Park Laboratory

Stem Cells and Cancer
Organoids
We study stem cells and cancer using genetically engineered mice and organoids with a specific interest in Wnt signaling.   
Wnt signaling plays key roles in governing various cellular processes during embryogenesis, organogenesis, and tissue homeostasis. We are exploring how Wnt signaling controls tissue stem and progenitor cells and orchestrates tissue regeneration. Aberrant activation of Wnt signaling contributes to cancer. Given the crucial roles of Wnt signaling in tissue homeostasis and regeneration, direct targeting of Wnt signaling as a cancer treatment is challenging. To overcome this, we are in the study of new molecules, cancer-specific regulators of Wnt signaling, in pre-clinical model systems. 
Updates

Welcome, BongJun! (10/2020)

Wnt blockers to ameliorate pain induced by chemotherapy (10/2020; accepted) 

R01 renewed (8/2020)

Welcome, Shengzhe! (7/2020)

2nd CPRIT Investigator-Initiated Research Award (2/2020)

As a tenure-track Assistant Professor, Youn-Sang will run his own lab at Chung-Ang University, Seoul, Korea (starting 3/2020)

Welcome, Yuanjian! (1/2020)

Biyun Zheng served as a hostess for the National competition of Digestive Elite (Shenzhen, China) and won the '2nd Prize of National Intestinal Disease Case Speech Competition' and the 'Best Popularity Award' (Peking, China; 11/2019).

Youn-Sang Jung received AACR-KCA Young Investigator Award (Nov 2019).

Moon Jong Kim received the ROSI seed grant (Aug 2019). 'Radiation-induced esophagitis and regeneration'

Youn-Sang Jung was nominated as the Anne Eastland Spears Fellow in GI Cancer Research (May 2019). 'Mechanism of diffuse-type gastric cancer initiation'

Youn-Sang Jung received the AACR Gastric Cancer Research - Debbie's DREAM foundation Fellowship

(April 2019).

CRAD, a new tumor suppressor in mucinous colorectal cancer

We identified a new tumor suppressor gene encoding CRAD (cancer-specific regulator of actin dynamics). We found that genetic mutations or transcriptional downregulation of CRAD initiates the development of mucinous colorectal cancer. 

 

Youn-Sang Jung et al., Nature Cell Biology  20, 1303-1314, 11/2018News & Views 

Targeting proton pump for colorectal cancer treatment

We found a new oncogene, TMEM9 (transmembrane protein 9), as an amplifier of Wnt/beta-catenin signaling. Importantly,  molecular targeting of TMEM9-v-ATPase suppresses colorectal cancer.

Youn-Sang Jung et al., Nature Cell Biology  20:1421-1433, 12/2018

PAF+ intestinal stem cells

A shared path to two destinations: PAF-Myc axis in tissue regeneration and cancer

Upon tissue injury, stem and progenitor cells exponentially repopulate for tissue repair. It was assumed that many signaling pathways might play critical roles in both normal tissue regeneration and tumorigenesis. We found that regenerating and cancer cells specifically express PAF (PCNA-associated factor). Importantly, PAF is required for expansion of self-renewing cells during intestinal regeneration and tumorigenesis, unveiling a pivotal signaling axis in both tissue repair and cancer. 

 

Moon Jong Kim et al., Developmental Cell 2018

Visualizing and manipulating self-renewing cells: Tert, a catalytic subunit of telomerase, is specifically expressed in self-renewing cells. We engineered mice to visualize and genetically manipulate Tert-expressing self-renewing cells. We found that Tert+ cells are quiescent stem cells conditionally activated by Wnt2/beta-catenin signaling for tissue regeneration. 

 

Han Na Suh et al., Cell Reports 2017
 

© 2017 by Jae-Il Park Laboratory

MD Anderson Cancer Center

Immunofluorescent staining of mouse intestine. PAF-expressing cells (red), Ki67 (green), DAPI (blue)